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Malignant Brenner Tumor

slide 47 of 56

Comments:
Malignant Brenner tumors show cytologically malignant areas (usually resembling high-grade urothelial carcinomas of the urinary tract) with stromal invasion. The tumor cells are arranged in solid sheets, irregularly shaped nests, or branching trabeculae. They usually have high-grade features, including pleomorphic hyperchromatic nuclei, brisk mitotic activity, central necrosis producing comedocarcinoma-like pattern, and desmoplastic stromal response. A benign Brenner tumor is seen on the left in this image. The appearance of the malignant component may be transitional (seen here), squamous, glandular, undifferentiated or mixed.

slide 47 of 56