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Desmoplastic Small Round Cell Tumor : NSE

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Desmoplastic small round cell tumors (DSRCT) are characterized by co-expression of epithelial, mesenchymal, and neural markers.

POSITIVE: Majority of the cases are positive for cytokeratin AE1/AE3, EMA, vimentin, desmin (paranuclear dot-like positivity), WT1 (antibody to carboxy terminus; nuclear expression) and NSE (shown here).

NEGATIVE: The tumor cells are negative for CK20, CK5/6, MyoD1, and myogenin.

OCCASIONALLY POSITIVE: The markers that are sometimes positive include: CD99, synaptophysin, chromogranin, neurofilament, S-100 protein, and CA-125.

Image courtesy of Dr. Jean-Christophe Fournet, Paris, France; humpath.com; Used with permission

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