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Large Cell NE Carcinoma

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At low magnification, large cell neuroendocrine carcinoma has more eosinophilic appearance than small cell carcinoma due to abundant cytoplasm. The tumor cells are arranged in solid sheets, organoid nests with peripheral palisading, or anastomosing trabeculae. Multiple rosettes forming cribriform structures and large areas of geographic necrosis are other commonly seen features.

This intermediate magnification view shows a few large nests with central necrosis.

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