Intratubular Germ Cell Neoplasia
Intratubular germ cell neoplasia (IGCN) in a cryptorchid testis. Cryptorchidism increases the risk for testicular germ cell tumors by 3.5 to 5 fold. About 2% to 8% of patients with cryptorchidism have IGCN. In unilateral cryptorchidism, the non-cryptorchid testis is also at a slightly higher risk of developing germ cell tumors. The most common subtype of IGCN is the unclassified variety. The tubules contain atypical germ cells with clear cytoplasm (due to glycogen content). The basement membrane is hyalinized and thickened.