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Pheochromocytoma

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This case shows nests and clusters of tumor cells with abundant dense amphophilic cytoplasm separated by a highly vascular stroma. The cytoplasm is granular due to the presence of membrane-bound, electron-dense secretory granules containing catecholamines. The nuclei are round or oval with one or more prominent nucleoli. Some of nuclei show degenerative atypia consisting of smudged chromatin.

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