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Metanephric Adenoma : Immunohistochemistry - CD57

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Comments:
The immunohistochemical profile of metanephric adenomas (MA) is as follows:

  • POSITIVE: WT1 (strong, nuclear), PAX8 (strong, nuclear), CD57 (cytoplasmic/membranous)
  • NEGATIVE: CK7 (may be weak, patchy +), AMACR

  • The combination of CK7-, AMACR-, CD57+ and WT1+ is considered characteristic of metanephric adenoma. Strong diffuse positivity for CK7 and AMACR argues against the diagnosis of MA and favors papillary renal cell carcinoma in the appropriate morphologic context.

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