Treatment & Prognosis: Cardiac rhabdomyomas show a striking tendency to undergo spontaneous regression. Between 50-70% of cardiac rhabdomyomas in infants will regress both in size and number, especially in the setting of TS. In older children, regression is less likely. Surgical intervention is not recommended unless they cause severe arrhythmias, valve obstruction, or congestive heart failure. Partial resection of the tumor is usually sufficient to relieve symptoms. In any case, complete surgical resection is often difficult due to their location deep within the myocardium. Unresectable rhabdomyomas in the setting of tuberous sclerosis may also be treated with Everolimus – the inhibitor of mTOR pathway.