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Homer-Wright Rosettes

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Adrenal_Neuroblastoma19_PoorlyDiff.jpg

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Homer-Wright rosettes are seen in 25 to 30% of neuroblastomas, usually in poorly-differentiated subtype. They consist of an arrangement of tumor cells around a central area (not a lumen, canal, or a blood vessel) filled with neurofibrillary processes. Several rosettes can be seen in this image along with foci of calcification.

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