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Clear Cell Adenofibroma

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Clear cell cystadenoma/adenofibroma is a benign tumor composed of simple glands lined by bland cuboidal or flattened cells with clear or lightly eosinophilic cytoplasm in a background of fibromatous stroma. Adenofibromas have a more prominent stromal component as compared to cystadenomas.

They are uncommon tumors, usually seen in association with endometriosis, and may be discovered incidentally. Grossly, they are solid tumors with a smooth external surface. The cut surface is solid, gray-white with small cysts.

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