Pineal parenchymal tumors show immunoreactivity for a variety of neuroendocrine markers such as neurofilament, synaptophysin (shown here), neuron-specific enolase, chromogranin, and CD56. The immunoreactivity in pineoblastomas is variable, heterogenous, and may even be absent. Courtesy of: Dr. Luciano de Souza Queiroz, Dept. of Pathology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo State, BRAZIL. Additional images are here.