Hepatosplenic T-cell Lymphoma
Malignant T cells are small to intermediate in size with regular oval or folded nuclei; occasional cells may be larger with highly atypical nuclei. Two variants of hepatosplenic T cell lymphomas are known: Alpha-beta variant expresses T cell receptors alpha-beta and shows female preponderance (younger than 13 yrs. and older than 50 yrs). Gamma-delta variant expresses T cell receptor gamma-delta chains and is more common in young males. Both variants carry poor prognosis.