Superficial spreading melanoma (SSM) is the most common clinico-pathologic subtype accounting for almost 70% of all cutaneous melanomas. It can occur anywhere on the body but has a predilection for lower leg in females and upper back in males. The three other subtypes include lentigo maligna melanoma, acral lentiginous melanoma, and nodular melanoma. SSM usually has a flat or slightly elevated surface than the surrounding uninvolved skin, irregular margins with indentations, notches or scalloping, and variable pigmentation. The color ranges from tan, pink, white, brown, blue, and black. The lighter tan or pink areas in a deeply pigmented lesion usually correspond to foci of spontaneous regression. The amelanotic variants are flesh-colored or appear erythematous. If one or more elevated firm blue-black nodules appear on the surface (as clearly seen in this image), it usually indicates the development of deep dermal invasion. Image courtesy of: Anna Coleman, CT(ASCP).