Chordoma of Clivus
Chordomas arising in the spheno-occipital region (shown here) may cause symptoms referable to compression of cranial nerves (especially optic nerve) and pituitary gland. Some cases extend inferiorly causing nasal obstruction. The appearance is typical of chordomas arising elsewhere. The tumor cells have abundant eosinophilic cytoplasm with moderate nuclear atypia and form anastomosing cords.