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Plasmablastic Lymphoma

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Plasmablastic lymphoma is a highly aggressive variant of diffuse large B-cell lymphoma (DLBCL) seen mainly in immunodeficient patients [HIV (most common), organ transplant recipients, autoimmune diseases]. The most commonly involved location is the oral cavity. Other sites of involvement include nasal cavity, gastrointestinal tract, lungs, skin, bone, and soft tissues. There is a striking male predominance and the median age is 4th and 5th decades of life.

The tumor is composed of sheets of plasmablasts with a "starry sky pattern" as depicted here.The tumor cells are large with eccentric nuclei, single central prominent nucleolus, and abundant basophilic cytoplasm. Mature plasma cells are rare. Mitotic activity and apoptosis are prominent.

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