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Pleomorphic Adenoma

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The stroma of pleomorphic adenoma (PA) is synthesized by the myoepithelial cells and can have myxoid to chondromyxoid, fibrous or vascular appearance. This image of PA shows a circumscribed tumor with peripheral epithelial component with acinar and tubular pattern and inner stromal component made up of chondroidmyxoid matrix. Grossly, the foci of cartilaginous differentiation appear translucent bluish-white. This feature is commonly seen in parotid and submandibular tumors. PA arising in minor salivary glands rarely show cartilaginous matrix production.

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