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DLBCL : Ovary

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HemePath_DLBCL_Ovary2.jpg

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Primary lymphomas of the female genital tract are quite rare. The most commonly affected sites (in order of frequency) are ovaries, uterine cervix, uterine corpus, vagina, vulva, and fallopian tube. Majority of the cases are B-cell lymphomas.

Primary ovarian lymphomas are seen over a wide age range with a peak incidence in the 4th and 5th decades of life. In adults, diffuse large B-cell lymphoma (DLBCL) is the most common subtype. In the pediatric age group, most cases are Burkitt lymphoma. The patients usually present with abdominal pain and distension. Fatigue, fever, and weight loss may also be present. About 50% of the cases are bilateral and approximately two-thirds involve extra-ovarian sites such as pelvic or para-aortic lymph nodes, omentum, and fallopian tubes.

The image shows DLBCL arising in the ovary. Atypical lymphoid cells are scattered in a sclerotic background. The immunohistochemical findings were diagnostic of DLBCL.

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