Facebook Icon Twitter icon Instagram icon Feedback

Pheochromocytoma : Immunohistochemical profile

prev slide 41 of 60 next
No Image
Adrenal_PheoA9_6.jpg

Close

Comments:
Pheochromocytoma cells have finely granular basophilic or amphophilic cytoplasm. With electron microscopy, the cells show numerous dense-core neurosecretory granules containing catecholamines and other peptides. Immunohistochemically, they are positive for catecholamines, NSE, chromogranin, and synaptophysin. They may also be reactive for neurofilaments, serotonin, calcitonin, gastrin, vasoactive intestinal peptide, corticotropin and numerous other neuronal markers. Other markers that are positive in some cases include cytokeratin, vimentin, and HMB-45. The sustentacular cells surrounding tumor cell nests stain with S-100 protein immunostain (see image 35).

prev slide 41 of 60 next