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Pheochromocytoma : S100, Sustentacular Cells

slide 35 of 60

Comments:
The tumor cell nests of pheochromocytoma (Zellballen) are surrounded by a layer of sustentacular cells which are difficult to appreciate on routine H&E stains but can be striking with S-100 protein immunostain. They are more numerous in benign cases and in those associated with MEN syndromes.

slide 35 of 60