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Pheochromocytoma : Nuclear Atypia

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Comments:
Pheochromocytomas frequently show atypical nuclear features, including striking hyperchromasia, giant nuclei, nuclear inclusions resulting from cytoplasmic invaginations, and bizarre forms. Many giant nuclei have smudged chromatin with a degenerative appearance. These changes are often distributed focally. None of these features signify aggressive behavior.

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