Pineal parenchymal tumors show immunoreactivity for a variety of neuroendocrine markers such as neurofilament (shown here), synaptophysin, neuron-specific enolase, chromogranin, and CD56. Note the intense positivity in the cellular processes in the center of the rosettes. Courtesy of: Dr. Luciano de Souza Queiroz, Dept. of Pathology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo State, BRAZIL. Additional images are here.