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Hirschsprung Disease

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Comments:
Full thickness section from a resection specimen showing the absence of ganglion cells in both submucosal and myenteric plexuses in a case of short segment Hirschsprung disease. The presence of hypertrophic submucosal nerve fibers (seen on the left in this image) are an additional helpful feature in making the diagnosis. The presence of acetylcholinesterase positive cholinergic nerve fibers within the lamina propria (a feature not present in normal individuals) is additional supportive evidence for the diagnosis of Hirschsprung disease. This stain can be performed only on frozen sections.

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