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SLL in Skin

slide 31 of 45

Comments:
Another case of cutaneous involvement in CLL. This punch skin biopsy is from a 67 y/o woman who presented with a large lesion in her lower extremity. CBC showed WBC count of over 200,000 with absolute lymphocytosis. Dermis and subcutaneous tissues show a lymphocytic infiltrate with irregular distribution. A Grenz zone is present. Proliferation centers or reactive lymphoid follicles are not seen. The lymphocytic infiltrate was positive for CD5, CD43, CD20, and CD23. CD10 was negative.

slide 31 of 45