Cutaneous involvement has been reported in between 4%-45% of cases with CLL. The most commonly affected areas are face, scalp, upper trunk, and extremities. The leukemia skin infiltrates appear as red or violaceous plaques, nodules, or bullous lesions. In some cases, there is blister formation or ulceration. Mucosal involvement is extremely uncommon. The lymphocytic infiltrate is distributed in a perivascular, periadnexal, nodular (shown here), diffuse, or band-like patterns. It is composed predominantly of a population of small, uniform lymphocytes with condensed chromatin and scant cytoplasm.