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Leiomyomatosis Peritonealis Disseminata

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Leiomyomatosis peritonealis disseminata (LPD) is a rare disorder characterized by the presence of numerous leiomyomas scattered throughout the peritoneum and omentum. It is most commonly seen in women in the reproductive age group, but may occasionally occur after menopause. It may be discovered incidentally or may cause symptoms due to mass effect.

The tumors range in number from a few to hundreds and the size ranges from a few millimeters to 2.5 cm. Histologically, they are leiomyomas and do not show any atypia, necrosis, or increased mitotic activity. Rare cases may undergo sarcomatous transformation. The differential diagnosis includes - metastatic leiomyosarcoma, metastatic carcinoma (clinically and grossly), and seeding of abdominal cavity following morcellation procedures. Treatment is surgical in symptomatic cases. Image courtesy of Dr. Nejib Ben Yahia, Tunisia; Used with permission

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