Gynecomastia is enlargement of male breast due to hypertrophy and hyperplasia of both glandular and stromal elements. The causes include hormonally-active tumors, cirrhosis, and drugs etc. The pathophysiologic mechanism is increased estrogen activity, decreased androgen activity or a combination of both. The image shows ducts surrounded by stroma showing changes reminiscent of pseudoangiomatous stromal hyperplasia.
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