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Papillary Urothelial Carcinoma, High-grade (WHO/ISUP Classification, 2004)

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Comments:
High-grade papillary urothelial carcinomas display total architectural disorganization and significant cytologic atypia of urothelium that can be recognized even at low power. There is loss of nuclear polarity; considerable variation in nuclear size, shape, and chromatin content; mitoses are frequent and may be abnormal. Umbrella cells are usually absent.

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