Dysgerminoma : Genetics
Dysgerminomas, like seminomas, show chromosome 12p gains in the form of isochromosome 12p. About 25-50% of dysgerminomas have point mutations in c-kit gene which encodes for KIT – a tyrosine kinase receptor. The mutations are localized to exon 17, codon 816. The image shows clusters of polygonal tumor cells with clear or lightly eosinophilic cytoplasm separated by delicate fibrous septa.