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Schwannoma : Ancient Change

slide 47 of 56

Comments:
Degenerative-type cytologic atypia is frequently seen in deep-seated schwannomas arising in the posterior mediastinum or retroperitoneum. It consists of irregular, multilobed hyperchromatic nuclei which frequently contain intranuclear vacuoles. Mitotic activity is not increased. These changes have no prognostic significance.

slide 47 of 56