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Low-grade Fibromyxoid Sarcoma

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SoftTissue_LowGradeFibromyxoidSarcoma2.jpg

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This focus shows greater cellularity than the previous image (same case). The stroma is largely fibrous - a small myxoid focus is seen on the extreme right. Both low-grade fibromyxoid sarcoma (LGFMS) and hyalinizing spindle cell tumor with giant rosettes carry the same translocation t(7;16) which results in FUS/CREB3L2 fusion. LGFMS carries the risk of multiple local recurrences and even pulmonary metastases.

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