Striving to be the most comprehensive online resource for high-quality pathology images

 

Extra-Abdominal Fibromatosis (Desmoid Tumor)

prev  
slide 6 of 18
next
No Image
SoftTissue_Fibromatosis_ExtraAbdominal6_MyxoidMatrix.jpg

Close

Comments:
Some cases of fibromatosis show myxoid matrix. Majority of the deep-seated fibromatoses show mutations in beta-catenin or APC genes - both of which are components of WNT signaling pathway. This results in nuclear accumulation of beta-catenin. The myofibroblastic cells are also positive for vimentin, SMA, MSA, calponin, desmin (rare cases, focally) and negative for CD34.

prev
slide 6 of 18
next