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Large Cell NE Carcinoma : Molecular Genetics

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Comments:
The molecular pathogenesis of large cell neuroendocrine carcinoma (LCNEC) is similar to that of small cell lung carcinoma (SCLC) but quite different from that of carcinoids. Mutational inactivation of TP53 and RB genes is seen almost universally. Additional details are here.

slide 42 of 92