7985 Images : Last Website Update : November 5, 2017
Follow us:        
Advertise With Us!

Large Cell NE Carcinoma : Immunostains

slide 40 of 92

Comments:
Large cell neuroendocrine carcinomas (LCNEC) express one or more of the neuroendocrine markers chromogranin, synaptophysin, NCAM/CD56 and others. NCAM/CD56 is highly sensitive but less specific for LCNEC. TTF-1 is positive in about 50% of cases. Napsin A expression is seen only in rare cases. LCNEC is positive for pancytokeratin, low molecular weight cytokeratins, and CK7. Squamous cell carcinoma-related markers such as CK5/6 and p40 are usually negative. Ki-67 labeling index is high, usually between 40% and 80%. CD117 (positive in 70% cases) is an indicator of adverse prognosis.

The image shows chromatin diffusion and encrustation of DNA from the necrotic tumor cells onto the vessel wall. It is referred to as Azzopardi effect.

slide 40 of 92