High-power view of plasma cell type shows massive infiltration of the interfollicular region by plasma cells. Occasionally, the plasma cells may be multinucleated or show atypia. The solitary form of Castlemanís disease (usually hyaline-vascular type) can be treated by surgical excision. The long-term prognosis of systemic form of Castlemanís disease (usually plasma cell type) is poor and it may evolve into a clonal lymphoproliferative disorder.
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