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Adenoid Cystic Carcinoma : Molecular Genetics

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AdCC of salivary glands, breast and other locations carry a specific chromosomal translocation t(6;9)(q22-23;p23-24) resulting in MYB-NFIB gene fusion which can be detected by FISH as well as RT-PCR.

MYB (6q23.3) Rearrangement by FISH: Translocations between MYB (6q23.3) and NFIB (9p24) can be confirmed by FISH with MYB break-apart probes. The result is interpreted as positive for MYB gene rearrangement when the red and green probes are separated (arrows). MYB overexpression has been detected immunohistochemically in tumors with and without MYB-NFIB fusion. Image courtesy of : Dr. Ryanne Brown, Stanford University; used with permission.

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