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Apocrine Carcinoma of Breast

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Comments:
Apocrine carcinoma comprises 1% to 4% of breast cancers. The diagnosis should be reserved for cases with clear-cut architectural features of a malignant tumor and a predominant apocrine morphology. The tumor cells have vesicular nuclei, prominent nucleoli, abundant eosinophilic cytoplasm and may show apocrine snouts. They are usually positive for GCDFP-15 whose coding gene is on chromosome 7q.

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