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Signet Ring Cell CA : Breast

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Breast_LobularCA64_SignetRing.jpg

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Strands and cords of signet ring cells are seen infiltrating adipose tissue. Signet ring cell carcinoma of the breast lacks alpha-catenin activity secondary to mutations. They are positive for CK7 and MUC1. They also lack E-Cadherin expression similar to classical lobular carcinoma.

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