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Signet Ring Cell CA : Breast

slide 52 of 53

Comments:
Strands and cords of signet ring cells are seen infiltrating adipose tissue. Signet ring cell carcinoma of the breast lacks alpha-catenin activity secondary to mutations. They are positive for CK7 and MUC1. They also lack E-Cadherin expression similar to classical lobular carcinoma.

slide 52 of 53