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Hepatocellular Carcinoma - Trabecular Pattern

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Comments:
The trabecular (sinusoidal) pattern of HCC comprises thickened trabeculae of large, polygonal, eosinophilic tumor cells, which are separated by a network of vascular channels lined by endothelium. This endothelial lining is a helpful diagnostic feature in fine-needle aspirates. HCCs lack portal tracts, Kupffer cells (CD68+), and cohesive connective tissue frameworks this often leads to artifactual spaces between trabeculae in cytologic and surgical specimens. Note the abundant eosinophilic cytoplasm and mild nuclear atypia in this well-differentiated tumor.

slide 42 of 64