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Herpes Simplex Virus Hepatitis

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Adjacent to the characteristic irregular zones of necrosis in HSV hepatitis, the infected hepatocytes demonstrate intranuclear inclusions (eosinophilic Cowdry type A or basophilic Cowdry type B) surrounded by clear halos with peripheral chromatin margination (ground-glass nuclei). Viral particles can be identified within hepatocytes and specific immunostains are available for confirmation and to exclude other viruses (e.g. CMV).

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