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Salivary Duct Carcinoma : Molecular Genetics

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Comments:
A variety of molecular and genetic rearrangements have been described in salivary duct carcinomas. Most important are LOH in chromosome 9p21, 6q, 16q, 17p, 17q and HER-2 gene amplification (up to 36% cases). Frequently TP53 gene mutation and deletion of PTEN are also found.

This case showed squamous differentiation in the form of abundant eosinophilic cytoplasm, intercellular bridges and small keratin pearls.

slide 81 of 143