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Sclerosing Polycystic Adenosis

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Comments:
Higher magnification showing a combination of apocrine and mucoid cells with zymogen-like granules. The clinical behavior is generally benign. However, some cases show enough atypia to consider the diagnosis of a low-grade malignant neoplasm. Some studies have shown that the lesion is clonal, further generating controversy as to its true nature. Image courtesy of: Dr. Simon Chiosea, Associate Professor of Pathology, Univ. of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

References:1. Sclerosing polycystic adenosis of major salivary glands. A clinicopathologic analysis of nine cases.Smith BC, Ellis GL, Slater LJ, Foss RD. Am J Surg Pathol. 1996 Feb;20(2):161-70. 2. Sclerosing polycystic adenosis of the salivary gland: a report of 16 cases. Gnepp DR, Wang LJ, Brandwein-Gensler M, Slootweg P, Gill M, Hille J. Am J Surg Pathol. 2006 Feb;30(2):154-64.

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