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GIST in NF1

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SoftTissue_PeripheralNerve_NF1_GIST4_resized.jpg

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Gastrointestinal stromal tumors (GIST) are seen in about 7% of neurofibromatosis 1 (NF1) patients. They show somatic inactivation of wild-type NF1 allelle but lack the PDGFRA and c-kit mutations seen in typical GIST.

Image courtesy of: Cody Carter, MD, Dept. of Pathology, Univ. of Michigan, Ann Arbor, Michigan.

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