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1:
Thymic Carcinoma : Well-differentiated Non-Keratinizing Epidermoid Carcinoma
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Comments: Thymic carcinomas are epithelial tumors of the thymus with clear-cut features of malignancy. They are usually not associated with myasthenia gravis and lack immature T lymphocytes. If lymphocytes are present, they are usually mature T (or B) cells. Thymic carcinomas are similar in appearance to corresponding tumors arising in other locations. The image shows non-keratinizing squamous cell carcinoma.
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3:
Thymic Carcinoma : Lymphoepithelioma-like
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Comments: This tumor share morphologic features with its homonymous counterpart in tonsil and nasopharynx. Cytoplasmic borders are indistinct creating a syncytial appearance. Numerous mature T lymphocytes are present in the background.
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4:
Thymic Carcinoma : Lymphoepithelioma-like
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Comments: Tumor cells in lymphoepithelioma-like thymic carcinoma have large, round, vesicular nuclei with prominent nucleoli. The tumor cells are positive for keratin and many cases contain EBV genome.
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6:
Thymic Carcinoma : Clear cell
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Comments: Large amount of glycogen-rich cytoplasm creates superficial resemblance to renal cell carcinoma in this case.
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7:
Thymic Carcinoma : Small Cell type
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Comments: The appearance is indistinguishable from its counterpart arising in the lung. Therefore, the diagnosis of a primary thymic small cell carcinoma should only be entertained after mediastinal metastasis from a pulmonary primary have been excluded.
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