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1:
Bladder : Hemangioma
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Comments: Vesical hemangiomas are uncommon benign lesions that usually present with gross hematuria. A cavernous hemangioma is shown in this image. Most lesions are small and can be effectively treated by biopsy and fulguration of the site. Cancer 1999 Aug; 86(3):498-504.
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2:
Bladder : Neurofibroma
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Comments: This is a bladder biopsy from a teenage boy with Neurofibromatosis Type 1 showing a diffuse neurofibroma. Attenuated urothelium is seen in the upper right. The lamina propria shows a proliferation of pseudo-meissnerian corpuscles.
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3:
Bladder : Neurofibroma
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Comments: The deeper aspect of the lesion shows an appearance more typical of a neurofibroma. Neurofibroma of urinary bladder generally presents in the setting of neurofibromatosis type 1 in early childhood. Most cases are plexiform type with a diffuse component. Cancer 1999 Aug; 505-13.
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4:
Bladder : Solitary Fibrous Tumor
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Comments: Solitary fibrous tumor may involve seminal vesicle, prostate, urinary bladder (shown here) and numerous other thoracic and extrathoracic sites. Due to their rarity, solitary fibrous tumors arising in urinary tract may be mistaken for sarcoma. This image shows plump spindle cells with round or oval vesicular nuclei and prominent vascularity. Hum Pathol 2000 Jan; 31(1):63-8.
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5:
Bladder : Angiosarcoma
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Comments: Primary angiosarcoma of urinary bladder is extremely rare. Exposure to arsenic, thorium dioxide, polyvinyl chloride, radiation, and chemotherapeutic agents etc. are risk factors. This bladder biopsy shows anastomosing vascular channels lined by atypical endothelial cells just beneath urothelial lining.
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6:
Bladder : Angiosarcoma
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Comments: The atypical endothelial cells have large vesicular nuclei with prominent nucleoli. The prognosis of vesical angiosarcoma is grim. Arch Esp Urol 1993 May; 46(4):351-3.
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7:
Bladder : Embryonal Rhabdomyosarcoma, Botyroid type
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Comments: Botyroid rhabodmyosarcomas occur in mucosa-lined hollow organs such as nasal cavity, urinary bladder (shown here), and vagina. Note the cambium layer consisting of subepithelial condensation of tumor cells. The deeper regions of the tumor show hypocellularity and abundance of myxoid stroma.
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8:
Bladder : Embryonal Rhabdomyosarcoma, Spindle type
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Comments: Spindle cell type of embryonal rhabdomyosarcoma is consists of relatively uniform spindle-shaped cells scattered in abundant myxoid stroma. Several mitotic figures are evident in this image.
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9:
Bladder : Embryonal Rhabdomyosarcoma, Spindle type
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Comments: The tumor cells have elongated cigar-shaped nuclei and eosinophilic fibrillar cytoplasm. The prognosis of spindle cell rhabdomyosarcoma is more favorable compared to conventional embryonal rhabdomyosarcoma.
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10:
Bladder : Embryonal Rhabdomyosarcoma
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Comments: Well-differentiated embryonal rhabdomyosarcomas such as this case have abundant rhabdomyoblasts containing deeply eosinophilic cytoplasm. In good histologic preparations, cross striations may be evident. Recurrent tumors following therapy may occasionally be composed entirely of rhabdomyoblasts.
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11:
Bladder : Leiomyosarcoma
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Comments: The image shows the usual histologic features of leiomyosarcoma – interlacing fascicles of spindle cells with markedly atypical nuclei and increased mitotic activity. Distinction of leiomyosarcomas from leiomyomas arising in urinary bladder is based upon the presence of infiltrative borders, mitotic activity, coagulative necrosis, and cellular atypia in the former. Am J Surg Pathol; 2002 Mar; 26(3):292-300.
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12:
Bladder : Epithelioid Leiomyosarcoma
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Comments: The tumor is composed of plump epithelioid cells with abundant eosinophilic cytoplasm and large vesicular nuclei with occasional prominent nucleoli.
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14:
Bladder : Radiation-induced Sarcoma
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Comments: Secondary malignancies, including sarcomas and carcinomas occasionally arise in the urinary bladder following radiation therapy for cervical and uterine cancers in females and for prostate cancer in males. This spindle cell sarcoma, NOS, arose in the bladder of a female patient several years after pelvic radiation for cervical cancer.
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