| Webpathology.com

Genitourinary Tract Genitourinary Tract

Home \| About this Site \| Feedback \| Site Map		Friday, September 10, 2010

Prostate : Metaplasia

Back to Prostate | Return to Genitourinary Tract

1: Mucinous Metaplasia in Prostate


	Comments: In this transurethral resection, clusters of mucinous glands lined by tall columnar cells are seen admixed with usual prostatic glands. The mucin is positive for mucicarmine, PAS, and alcian blue. The glands are negative for PSA and PAP.

2: Mucinous Metaplasia in Prostate


	Comments: The nuclei are small and basally located and lack prominent nucleoli. The differential diagnosis is with Cowper’s glands and adenocarcinoma.

3: Mucinous Metaplasia in Prostate Needle Biopsy


	Comments: Mucinous metaplasia in a needle biopsy of the prostate. Note partial involvement in one of the glands on the right.

4: Squamous Metaplasia : PSA Immunostain


	Comments: Mucinous glands are negative for PSA immunostain. Same case as previous slide.

5: Squamous Metaplasia in Prostate Needle Biopsy


	Comments: Squamous metaplasia in prostate can be seen in response to infarction, inflammation, radiation therapy, or androgen deprivation therapy.

6: Squamous Metaplasia in TUR Specimen


	Comments: Squamous metaplasia adjacent to an area of infarction in a transurethral resection specimen.

7: Urothelial Metaplasia in Prostate Needle Biopsy


	Comments: The central portions of the prostatic ducts are normally lined by urothelium. When urothelial lining is seen in more peripheral ducts and glands as in this needle biopsy, the term urothelial metaplasia is used.