Comments: The patient was a 60-yr old male who presented with a scrotal lesion of 5 months' duration. Clinically, it was worrisome for squamous cell carcinoma. Syringocystadenoma papilliferum is a benign neoplasm of apocrine/eccrine derivation that may occur on face, scalp, arms, thigh, scrotum, and trunk.
Comments: The papillae are lined by dual epithelial layer consisting of an inner low cuboidal layer with scant cytoplasm and an outer columnar layer. The papillae enclose a dense infiltrate of plasma cells.
Comments: The dual cell population is better appreciated here. This case showed mild cytologic atypia and increased mitotic activity. However, it was small and completely excised and expected to behave in a benign fashion.
