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1:
Granular Cell Tumor in Scrotum
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Comments: This granular cell tumor is from a 40 y/o male who presented with a slowly-expanding firm nodule in his perineum. The tumor has ill-defined borders and infiltrates into the dermis.
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2:
Granular Cell Tumor in Scrotum
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Comments: The tumor cells are round to polygonal with abundant eosinophilic granular cytoplasm and small uniform nuclei. The cells are arranged in nests, strands, cords, or sheets.
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3:
Granular Cell Tumor in Scrotum
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Comments: Granular cell tumors may cause pseudoepitheliomatous hyperplasia of the overlying squamous epithelium which may lead to the mistaken diagnosis of squamous cell carcinoma.
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4:
Granular Cell Tumor in Scrotum
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Comments: The granular appearance of cytoplasm is due to lysosomes with high content of enzymes such as acid phosphatase. The cytoplasmic granules show strong PAS positivity.
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5:
Granular Cell Tumor in Scrotum
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Comments: Strong immunoreactivity for S-100 was seen in this case. Most granular cell tumors pursue a benign course. There are well-documented cases of "benign-appearing" granular cell tumors that produced distant metastases. Features favoring malignancy include necrosis, high mitotic activity, spindling of tumor cells, and prominent nucleoli.
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