Epstein-Barr Virus Hepatitis
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![ID_EBV_Hepatitis3.jpg](/slides-13/slides/ID_EBV_Hepatitis3.jpg)
Comments:
EBV Hepatitis: Liver involvement is seen in >90% of patients with infectious mononucleosis. Most cases are subclinical. Symptoms develop in only 5-10% of patients. Microscopically, there are dense lymphocytic infiltrates in portal tracts and sinusoids. Large atypical lymphocytes may be found. In the sinusoids, these cells are arranged in single-file (Indian file) or string-of-beads pattern. Kupffer cells are hypertrophied. Infrequent findings include epithelioid granulomas, focal hepatocellular necrosis, and cholestasis.