Pheochromocytoma : Nuclear Atypia
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![Adrenal_PheoA5_3.jpg](/slides-13/slides/Adrenal_PheoA5_3.jpg)
Comments:
Pheochromocytomas frequently show atypical nuclear features, including striking hyperchromasia, giant nuclei, nuclear inclusions resulting from cytoplasmic invaginations, and bizarre forms. Many giant nuclei have smudged chromatin with a degenerative appearance. These changes are often distributed focally. None of these features signify aggressive behavior.